Ghislain Opdenakker Selected Research

Chemokines

11/2022	Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza.
1/2020	Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy.
2/2019	The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA-B27-associated uveitis.
1/2019	The ectoenzyme-side of matrix metalloproteinases (MMPs) makes inflammation by serum amyloid A (SAA) and chemokines go round.
10/2018	Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice.
1/2018	COOH-terminal SAA1 peptides fail to induce chemokines but synergize with CXCL8 and CCL3 to recruit leukocytes via FPR2.
1/2018	Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity.
1/2018	Immunomodulation as Rescue for Chronic Atonic Skin Wounds.
1/2018	Matrix Metalloproteinase-9-Generated COOH-, but Not NH2-Terminal Fragments of Serum Amyloid A1 Retain Potentiating Activity in Neutrophil Migration to CXCL8, With Loss of Direct Chemotactic and Cytokine-Inducing Capacity.
12/2017	Chemokine isoforms and processing in inflammation and immunity.

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Ghislain Opdenakker Research Topics

Disease

70	Inflammation (Inflammations) 04/2022 - 01/2002
36	Neoplasms (Cancer) 08/2020 - 07/2002
32	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 08/2006
20	Epiretinal Membrane (Epiretinal Membranes) 01/2022 - 02/2007
19	Infections 01/2021 - 11/2003
16	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 01/2003
14	Malaria 01/2020 - 05/2010
13	Uveitis 04/2022 - 09/2004
13	Multiple Sclerosis 01/2020 - 01/2003
11	Neoplasm Metastasis (Metastasis) 11/2016 - 07/2002
10	Necrosis 02/2020 - 12/2004
8	Fibrosis (Cirrhosis) 01/2022 - 12/2012
7	Hypoxia (Hypoxemia) 01/2022 - 02/2015
7	Rheumatoid Arthritis 01/2021 - 03/2002
7	Septic Shock (Toxic Shock Syndrome) 10/2017 - 08/2002
6	Cerebral Malaria 11/2019 - 09/2006
6	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2018 - 06/2003
6	Peritonitis 09/2009 - 01/2006
5	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2021 - 10/2010
5	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 11/2019 - 02/2010
5	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 03/2018 - 05/2010
5	Pancreatic Neoplasms (Pancreatic Cancer) 10/2017 - 01/2016
5	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2017 - 02/2014
5	Shock 01/2014 - 08/2002
5	Pancreatitis 04/2009 - 01/2003
4	Sarcoidosis (Schaumann Disease) 04/2020 - 01/2016
4	Adenocarcinoma 12/2016 - 07/2010
4	Virus Diseases (Viral Diseases) 02/2016 - 06/2003
4	Sepsis (Septicemia) 03/2015 - 08/2002
4	Melanoma (Melanoma, Malignant) 11/2014 - 09/2006
3	COVID-19 11/2022 - 11/2020
3	Arthritis (Polyarthritis) 01/2021 - 01/2006
3	Ulcerative Colitis 02/2020 - 07/2014
3	Colitis 01/2018 - 11/2016
3	Crohn Disease (Crohn's Disease) 11/2016 - 11/2005
3	Chronic Pancreatitis 01/2016 - 05/2003
3	Breast Neoplasms (Breast Cancer) 11/2014 - 01/2005

Drug/Important Bio-Agent (IBA)

68	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2021 - 01/2002
57	Matrix Metalloproteinases (MMPs)IBA 01/2021 - 03/2002
41	ChemokinesIBA 11/2022 - 07/2002
31	EnzymesIBA 01/2020 - 03/2002
30	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2002
24	CytokinesIBA 11/2022 - 05/2004
24	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 03/2002
17	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 07/2010
17	ImmunosorbentsIBA 01/2020 - 09/2004
16	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2013
12	Metalloproteases (Metalloproteinases)IBA 08/2020 - 09/2006
10	Matrix Metalloproteinase InhibitorsIBA 07/2019 - 06/2003
10	LigandsIBA 01/2018 - 11/2003
9	Pharmaceutical PreparationsIBA 01/2019 - 10/2006
9	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 01/2006
7	Chemotactic FactorsIBA 11/2022 - 05/2004
7	AutoantigensIBA 01/2022 - 01/2003
7	AutoantibodiesIBA 01/2022 - 12/2004
7	Retinaldehyde (Retinal)IBA 01/2022 - 02/2015
7	CXC ChemokinesIBA 11/2014 - 01/2004
7	Interleukin-8 (Interleukin 8)IBA 02/2014 - 01/2003
6	Peptides (Polypeptides)IBA 01/2022 - 01/2014
6	InterferonsIBA 01/2021 - 06/2003
6	oxyamylose (COAM)IBA 01/2014 - 10/2008
6	ZymosanIBA 09/2009 - 01/2006
5	Complement System Proteins (Complement)IBA 01/2021 - 09/2006
5	GelatinIBA 01/2021 - 02/2014
5	Tissue Inhibitor of Metalloproteinase-1IBA 01/2020 - 01/2013
5	Biological ProductsIBA 02/2018 - 07/2009
5	hemozoinIBA 01/2014 - 08/2011
4	Interleukin-17 (Interleukin 17)IBA 11/2022 - 12/2007
4	GelatinasesIBA 01/2021 - 09/2004
4	cobaltous chloride (cobalt(II)chloride)IBA 01/2021 - 12/2016
4	Streptozocin (Streptozotocin)FDA Link 01/2021 - 01/2003
4	Antiviral Agents (Antivirals)IBA 01/2021 - 10/2008
4	EpitopesIBA 01/2021 - 03/2002
4	Infliximab (Remicade)FDA Link 02/2020 - 11/2005
4	Insulin (Novolin)FDA Link 10/2018 - 01/2003
4	progelatinaseIBA 08/2014 - 12/2004
4	Toll-Like Receptors (Toll-Like Receptor)IBA 07/2010 - 11/2003
3	Protease Inhibitors (Protease Inhibitor)IBA 11/2022 - 02/2016
3	Anti-Bacterial Agents (Antibiotics)IBA 11/2022 - 09/2011
3	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2022 - 11/2019
3	Monoclonal AntibodiesIBA 04/2022 - 01/2014
3	GlycosaminoglycansIBA 01/2022 - 08/2012
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 02/2014
3	AntigensIBA 01/2021 - 01/2019
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 12/2016
3	Dexamethasone (Maxidex)FDA LinkGeneric 11/2019 - 05/2010
3	GlucocorticoidsIBA 11/2019 - 01/2016
3	InterleukinsIBA 08/2019 - 07/2010
3	Interleukin-10 (Interleukin 10)IBA 08/2019 - 05/2011
3	ProdrugsIBA 01/2019 - 05/2013
3	pro-matrix metalloproteinase 9IBA 01/2019 - 08/2011
3	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2019 - 03/2009
3	Interleukin-6 (Interleukin 6)IBA 06/2018 - 01/2016
3	EndopeptidasesIBA 01/2018 - 10/2007
3	ZincIBA 01/2018 - 10/2007
3	Dextrans (Dextran)FDA Link 01/2018 - 11/2016
3	Protein Isoforms (Isoforms)IBA 12/2017 - 07/2002
3	Minocycline (Cyclops)FDA LinkGeneric 01/2017 - 06/2003
3	Matrix Metalloproteinase 2 (Gelatinase A)IBA 11/2016 - 03/2004

Therapy/Procedure

18	Therapeutics 04/2022 - 06/2003